Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma
نویسندگان
چکیده
منابع مشابه
PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.
PURPOSE Inactivation of the tumor suppressor gene, phosphatase and tensin homologue (PTEN), is a major alteration in preclinical melanoma models. We investigated the clinical relevance of PTEN expression in the primary melanoma patients with extended follow-up. EXPERIMENTAL DESIGN We correlated PTEN expression with clinicopathologic variables and outcome in 127 primary melanomas (median follo...
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متن کاملHsp - 90 and
Background: Hsp-90 from the free-living nematode Caenorhabditis elegans is unique in that it fails to bind to the specific Hsp-90 inhibitor, geldanamycin (GA). Here we surveyed 24 different freeliving or parasitic nematodes with the aim of determining whether C. elegans Hsp-90 was the exception or the norm amongst the nematodes. We combined these data with codon evolution models in an attempt t...
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PURPOSE Conjunctival melanoma (CM) is a rare disease associated with considerable mortality. As opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear. The purpose of this study was to identify tumor-specific and prognostic microRNA (miRNA) in CM and to compare the miRNA profile with that of MM. METHODS Using mi...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2010
ISSN: 0007-1161
DOI: 10.1136/bjo.2010.183939